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Drug Interactions between sulfasalazine and turmeric

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

sulfaSALAzine turmeric

Applies to: sulfasalazine and turmeric

MONITOR: Coadministration with turmeric may increase the plasma concentrations of sulfasalazine. The proposed mechanism involves enhanced bioavailability of sulfasalazine due to inhibition of breast cancer resistance protein (BCRP)-mediated intestinal efflux by curcumin, an active constituent of turmeric. When a single 2 gm dose of sulfasalazine was administered orally to 8 healthy male volunteers 30 minutes following a 2 gm dose of curcumin, mean sulfasalazine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 3.7- and 3.2-fold, respectively, compared to administration of the sulfasalazine dose alone.

MANAGEMENT: Caution is advised when sulfasalazine is used with turmeric-containing products. Patients should be monitored for serious adverse effects of sulfasalazine such as blood dyscrasias, myelosuppression, infections, hepatotoxicity, and renal impairment.

References

  1. Kusuhara H, Furuie H, Inano A, et al. (2012) "Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP." Br J Pharmacol, 166, p. 1793-803

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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