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Drug Interactions between Proleukin and vinblastine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

vinBLAStine aldesleukin

Applies to: vinblastine and Proleukin (aldesleukin)

GENERALLY AVOID: Aldesleukin in combination with certain antineoplastic agents (cisplatin, dacarbazine, vinblastine) has been associated with fatal tumor lysis syndrome. Symptoms include hyperkalemia, hyperphosphatasemia, hyperuricemia, hypocalcemia, and acute renal failure. In addition, hypersensitivity reactions requiring medical intervention have been reported with the use of sequential high-dose aldesleukin and dacarbazine or cisplatin. Symptoms occurred within a few hours after chemotherapy administration and included erythema, pruritus, and hypotension.

MANAGEMENT: Concomitant use is not recommended.

References

  1. (2001) "Product Information. Proleukin (aldesleukin)." Chiron Therapeutics
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  4. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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