Drug Interactions between Proben-C and sodium phenylacetate
This report displays the potential drug interactions for the following 2 drugs:
- Proben-C (colchicine/probenecid)
- sodium phenylacetate
Interactions between your drugs
probenecid sodium phenylacetate
Applies to: Proben-C (colchicine / probenecid) and sodium phenylacetate
Ask your doctor before using probenecid together with sodium phenylacetate. Probenecid may decrease the effects of sodium phenylacetate for the treatment of acute hyperammonemia in patients with urea cycle disorders. Hyperammonemia is the presence of ammonia or some of its compounds in the blood, thought to be formed from the breakdown of urea. It usually results in low temperature, weak pulse, gastroenteric symptoms, and coma. It may be appropriate to avoid using probenecid during treatment of hyperammonemia due to the urgent nature of the condition. Uncontrolled hyperammonemia can rapidly result in brain damage or death. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
colchicine food
Applies to: Proben-C (colchicine / probenecid)
Drinking large amounts of grapefruit juice can increase your blood levels of colchicine to dangerous levels. You should avoid the consumption of grapefruit or grapefruit juice during treatment with colchicine. Let your doctor know if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet, as these may be early symptoms of colchicine toxicity.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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