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Drug Interactions between plasminogen, human and Toradol IM

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

ketorolac plasminogen, human

Applies to: Toradol IM (ketorolac) and plasminogen, human

MONITOR CLOSELY: Coadministration of plasminogen with anticoagulants, antiplatelets, or other agents that interfere with normal coagulation may prolong or worsen bleeding from active lesions and wounds. Plasminogen deficiency type 1 is characterized by the formation of fibrin-rich lesions on mucous membranes. Replacement therapy temporarily corrects plasminogen deficiency and reduces or resolves extravascular fibrinous lesions, which may prolong or worsen bleeding from any active lesion (disease-related or not), including GI bleeding, hemoptysis, epistaxis, vaginal bleeding, or hematuria. Clinical data are currently lacking.

MANAGEMENT: Caution is advised if plasminogen is used in patients taking anticoagulants, antiplatelets, or other agents that interfere with normal coagulation. Clinical and laboratory monitoring are recommended for 4 hours after infusion. If a patient develops any GI bleeding or bleeding from any other site that persists longer than 30 minutes, seek emergency care and discontinue plasminogen immediately.

References

  1. (2022) "Product Information. Ryplazim (plasminogen, human)." Prometic Biotherapeutics Inc

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Drug and food interactions

Moderate

ketorolac food

Applies to: Toradol IM (ketorolac)

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References

  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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