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Drug Interactions between Onfi and oxtriphylline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

oxtriphylline cloBAZam

Applies to: oxtriphylline and Onfi (clobazam)

Methylxanthines may antagonize the sedative effects of benzodiazepines. Aminophylline in particular has been demonstrated to attenuate the sedative effects of diazepam. The mechanism of this interaction may be related to competitive binding to intracerebral adenosine receptors. One study demonstrated that alprazolam serum concentrations were significantly lower in patients receiving chronic theophylline therapy than in patients not receiving theophylline. Clinical and laboratory monitoring is warranted if these agents are given concurrently. Patients receiving this combination should be monitored for adequate response to the benzodiazepine.

References

  1. Bonfiglio MF, Dasta JF (1991) "Clinical significance of the benzodiazepine-theophylline interaction." Pharmacotherapy, 11, p. 85-7
  2. Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet, 20, p. 135-50
  3. Stirt JA (1981) "Aminophylline is a diazepam antagonist." Anesth Analg, 60, p. 767-8
  4. Gallen JS (1989) "Aminophylline reversal of midazolam sedation." Anesth Analg, 69, p. 268
  5. Tuncok Y, Akpinar O, Guven H, Akkoclu A (1994) "The effects of theophylline on serum alprazolam levels." Int J Clin Pharmacol Ther, 32, p. 642-5
View all 5 references

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Drug and food interactions

Moderate

cloBAZam food

Applies to: Onfi (clobazam)

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References

  1. Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
  2. Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
  3. (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
  4. (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
View all 4 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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