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Drug Interactions between Nulecit and Vita-Plus E Natural

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

vitamin E sodium ferric gluconate complex

Applies to: Vita-Plus E Natural (vitamin e) and Nulecit (sodium ferric gluconate complex)

MONITOR: Limited data suggest that vitamin E may diminish the therapeutic response to iron therapy in patients with iron deficiency anemia. The mechanism has not been established. In a group of 26 anemic children treated with iron dextran for 3 days, nine patients who also received vitamin E (200 units starting one day before iron dextran) had a reticulocyte response of only 4.4%, compared to 14.4% in the other patients. The patients who received vitamin E also had reduced hemoglobin levels and lower hematocrit.

MANAGEMENT: Patients receiving iron therapy for iron deficiency anemia should be monitored for potentially reduced hematologic response if vitamin E is administered concomitantly.

References

  1. Graeber JE, Williams ML, Oski FA "The use of intramuscular vitamin E in the premature infant. Optimum dose and iron interaction." J Pediatr 90 (1977): 282-4
  2. Melhorn DK, Gross S "Relationships between iron-dextran and vitamin E in iron deficiency anemia in children." J Lab Clin Med 74 (1969): 789-802

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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