Drug interactions between mefloquine and Toprol-XL
Results for the following 2 drugs: |
|
|---|---|
| mefloquine | |
| Toprol-XL (metoprolol) | |
Interactions between your selected drugs
metoprolol ⇔ mefloquine
Applies to: Toprol-XL (metoprolol) and mefloquine
MONITOR: Mefloquine is a myocardial depressant and can cause ECG abnormalities. Theoretically, coadministration with other agents that can affect cardiac conduction (e.g., antiarrhythmic agents, beta blockers, calcium channel blockers, certain antihistamines, tricyclic antidepressants, phenothiazines, some neuroleptics) may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on cardiac conduction. Parenteral studies in animals have shown that mefloquine possesses 20% of the antifibrillatory action of quinidine and can cause 50% of the increase in PR interval reported with quinine. ECG alterations reported with mefloquine include sinus bradycardia, sinus arrhythmia, first degree AV block, prolongation of the QTc interval, and abnormal T waves. According to mefloquine labeling, there has been one report of cardiopulmonary arrest, with full recovery, in a patient who was taking a beta blocker (propranolol).
MANAGEMENT: Caution and clinical monitoring are recommended if mefloquine is used concurrently with other medications that can prolong the QT interval or otherwise affect cardiac conduction. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of arrhythmia such as dizziness, palpitations, or syncope.
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