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Drug Interactions between maraviroc and Voxsuprine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

isoxsuprine maraviroc

Applies to: Voxsuprine (isoxsuprine) and maraviroc

MONITOR: Maraviroc may potentiate the hypotensive effect of some medications. In clinical trials, symptomatic postural hypotension was observed more often with maraviroc than with placebo when administered to healthy volunteers at higher than recommended dosages. However, when given at the recommended dosage to HIV subjects, postural hypotension occurred at a rate similar to placebo (approximately 0.5%).

MANAGEMENT: Caution is advised when maraviroc is prescribed to patients on concomitant medications known to lower blood pressure. Close monitoring for development of hypotension is recommended. Ambulatory patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their doctor if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.

References

  1. "Product Information. Selzentry (maraviroc)." Pfizer U.S. Pharmaceuticals Group (2007):

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Drug and food interactions

Minor

maraviroc food

Applies to: maraviroc

Administration with food may reduce the bioavailability of maraviroc. According to the product labeling, coadministration of a 300 mg dose of maraviroc with a high-fat breakfast reduced maraviroc peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% in healthy volunteers. However, no food restrictions were used in the clinical studies that demonstrated the safety and efficacy of maraviroc. Therefore, maraviroc can be taken with or without food at the recommended dosage.

References

  1. "Product Information. Selzentry (maraviroc)." Pfizer U.S. Pharmaceuticals Group (2007):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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