Drug Interactions between lanthanum carbonate and rifampin
This report displays the potential drug interactions for the following 2 drugs:
- lanthanum carbonate
- rifampin
Interactions between your drugs
rifAMPin lanthanum carbonate
Applies to: rifampin and lanthanum carbonate
Lanthanum carbonate and rifAMPin should not be taken orally at the same time. These medications may interfere with each other's absorption into the bloodstream, which may reduce the effects of both medications. To minimize the potential for interaction, avoid taking rifAMPin within 2 hours of taking lanthanum carbonate. Talk to a healthcare professional if you have questions on how to take these or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
rifAMPin food
Applies to: rifampin
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Concurrent use of rifampin in patients who ingest alcohol daily may result in an increased incidence of hepatotoxicity. The increase in hepatotoxicity may be due to an additive risk as both alcohol and rifampin are individually associated with this adverse reaction. However, the exact mechanism has not been established.
ADJUST DOSING INTERVAL: Administration with food may reduce oral rifampin absorption, increasing the risk of therapeutic failure or resistance. In a randomized, four-period crossover phase I study of 14 healthy male and female volunteers, the pharmacokinetics of single dose rifampin 600 mg were evaluated under fasting conditions and with a high-fat meal. Researchers observed that administration of rifampin with a high-fat meal reduced rifampin peak plasma concentration (Cmax) by 36%, nearly doubled the time to reach peak plasma concentration (Tmax) but reduced overall exposure (AUC) by only 6%.
MANAGEMENT: The manufacturer of oral forms of rifampin recommends administration on an empty stomach, 30 minutes before or 2 hours after meals. Patients should be encouraged to avoid alcohol or strictly limit their intake. Patients who use alcohol and rifampin concurrently or have a history of alcohol use disorder may require additional monitoring of their liver function during treatment with rifampin.
References
- "Product Information. Rifampin (rifAMPin)." Akorn Inc (2022):
- "Product Information. Rifampicin (rifampicin)." Mylan Pharmaceuticals Inc (2022):
- "Product Information. Rifadin (rifampicin)." Sanofi (2023):
- "Product Information. Rifadin (rifaMPICin)." Sanofi-Aventis Australia Pty Ltd (2024):
- Peloquin CA, Namdar R, Singleton MD, Nix DE "Pharmacokinetics of rifampin under fasting conditions, with food, and with antacids https://pubmed.ncbi.nlm.nih.gov/9925057/" (2024):
- "Product Information. Rofact (rifampin)." Bausch Health, Canada Inc. (2019):
lanthanum carbonate food
Applies to: lanthanum carbonate
Take lanthanum carbonate tablets with food or immediately after a meal to increase absorption by the body. Lanthanum carbonate tablets cannot be dissolved in water and therefore should not be given through feeding tubes because the tube may become clogged. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.