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Drug Interactions between influenza virus vaccine, h1n1, live and rabies immune globulin, human

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

rabies immune globulin, human influenza virus vaccine, H1N1, live

Applies to: rabies immune globulin, human and influenza virus vaccine, h1n1, live

ADJUST DOSING INTERVAL: The passive transfer of antibodies present in immune globulin preparations may interfere with the immune response to live vaccines.

MANAGEMENT: Varicella virus vaccine should not be given for at least 5 months, and other live vaccines should not be given for at least 3 months, after administration of immune globulin. If such vaccinations are given shortly before or after immune globulin therapy, a revaccination may be necessary. Some experts have recommended that administration of measles virus vaccine be deferred for at least 8 months following human intravenous immune globulin therapy for immunodeficiency disease; 8 to 10 months following treatment for immune thrombocytopenic purpura (ITP); and at least 11 months following treatment for Kawasaki syndrome. In the event that immune globulin and measles virus vaccine must be administered concurrently, it is advisable to separate the injection sites by as much as possible and to administer an additional dose of vaccine at the appropriate specified interval. An additional dose of live measles, mumps, or rubella vaccine is usually not needed if the vaccine was administered at least two weeks prior to immune globulin administration. Hepatitis B immune globulin has been reported to not interfere with measles vaccination, although data are limited.

References

  1. "Interference of immune globulin with measles and rubella immunization." Eur J Pediatr 152 (1993): 536
  2. "Product Information. Sandoglobulin (immune globulin intravenous)." Sandoz Pharmaceuticals Corporation PROD
  3. "Product Information. Bayrab (rabies immune globulin, human)." Bayer PROD (2001):
  4. "Product Information. Varivax (varicella virus vaccine)." Merck & Co., Inc (2022):
  5. "Product Information. Attenuvax (measles virus vaccine)." Merck & Co., Inc (2022):
  6. "Product Information. Baygam (immunglobulin, intramuskulärt)." Bayer PROD
  7. CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18
  8. "Product Information. Thymoglobulin (immune globulin intravenous)." SangStat Medical Corporation, Menlo Park, CA.
  9. "Product Information. H-BIG (hepatitis B immune globulin)." Allscrips Pharmaceutical Company
  10. "Product Information. Cytogam (cytomegalovirus immune globulin)." CSL Behring LLC (2002):
  11. "Product Information. Varicella Zoster Immune Globulin (varicella zoster immune globulin)." American Red Cross Blood Services (2002):
  12. "Product Information. Baytet (tetanus immune globulin)." Bayer (2002):
  13. "Product Information. WinRho SDF (RHo (D) immune globulin)." Apothecon Inc (2022):
  14. "Product Information. BayRHo-D (RHo (D) immune globulin)." Bayer
  15. "Product Information. Bayhep B (hepatitis B immune globulin)." Bayer Pharmaceutical Inc (2022):
  16. "Product Information. Nabi-HB (hepatitis B immune globulin)." Biotest Pharmaceuticals Corporation (2022):
  17. "Product Information. Rhophylac (RHo (D) immune globulin)." Apothecon Inc (2022):
  18. "Product Information. HyperRHO S/D Full Dose (RHo (D) immune globulin)." Talecris Biotherapeutics (2022):
  19. "Product Information. Vivaglobin (immune globulin subcutaneous)." *ZLB Bioplasma Inc (2006):
  20. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  21. Canadian Pharmacists Association "e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink" (2006):
  22. "Product Information. BabyBIG (botulism immune globulin)." FFF Enterprises (2008):
  23. "Product Information. Hyperhep B (hepatitis B immune globulin)." Apothecon Inc (2022):
  24. "Product Information. Imogam Rabies-HT (rabies immune globulin, human)." sanofi pasteur (2010):
  25. "Product Information. Qdenga (dengue vaccine)." Takeda UK Ltd (2023):
View all 25 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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