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Drug Interactions between indomethacin and Skelid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

indomethacin tiludronate

Applies to: indomethacin and Skelid (tiludronate)

ADJUST DOSING INTERVAL: The bioavailability of tiludronate is increased 2 to 4 times in patients receiving concomitant indomethacin. The mechanism of the interaction is not known.

MANAGEMENT: The manufacturer recommends that indomethacin should not be taken within 2 hours before or 2 hours after tiludronate.

References

  1. "Product Information. Skelid (tiludronate)." Sanofi Winthrop Pharmaceuticals

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Drug and food interactions

Moderate

tiludronate food

Applies to: Skelid (tiludronate)

ADJUST DOSING INTERVAL: Food significantly decreases the bioavailability of tiludronate. The manufacturer reports up to a 90% decrease in bioavailability when administered with or 2 hours after a standard breakfast. Clinical efficacy, however, was demonstrated when tiludronate was taken 2 hours before or after meals.

MANAGEMENT: Tiludronate should be administered with 6 to 8 ounces of plain water at least 2 hours before or 2 hours after food.

References

  1. "Product Information. Skelid (tiludronate)." Sanofi Winthrop Pharmaceuticals

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Moderate

indomethacin food

Applies to: indomethacin

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References

  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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