Drug Interactions between Imbruvica and Uvadex
This report displays the potential drug interactions for the following 2 drugs:
- Imbruvica (ibrutinib)
- Uvadex (methoxsalen)
Interactions between your drugs
No interactions were found between Imbruvica and Uvadex. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Imbruvica
A total of 457 drugs are known to interact with Imbruvica.
- Imbruvica is in the drug class BTK inhibitors.
- Imbruvica is used to treat the following conditions:
Uvadex
A total of 139 drugs are known to interact with Uvadex.
- Uvadex is in the drug class psoralens.
- Uvadex is used to treat Cutaneous T-cell Lymphoma.
Drug and food interactions
ibrutinib food
Applies to: Imbruvica (ibrutinib)
GENERALLY AVOID: Coadministration with grapefruit, grapefruit juice, or Seville oranges may significantly increase the plasma concentrations of ibrutinib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Pharmacokinetic modeling suggests that other moderate CYP450 3A4 inhibitors such as diltiazem and erythromycin may increase ibrutinib systemic exposure (AUC) by 6- to 9-fold under fasting condition. The safety and efficacy of these exposures are unknown. The highest ibrutinib dose evaluated in clinical trials was 12.5 mg/kg (actual doses of 840 to 1400 mg) given for 28 days, which yielded single dose AUC values that were approximately 50% greater than steady-state exposures seen at the highest indicated dose of 560 mg.
ADJUST DOSING INTERVAL: Food increases the oral bioavailability of ibrutinib. The mechanism of interaction is unknown. According to the product labeling, administration with food increases ibrutinib exposure approximately 2-fold compared to administration after overnight fasting.
MANAGEMENT: Patients treated with ibrutinib should avoid consumption of Seville oranges, grapefruit, grapefruit juice, and any supplement containing grapefruit extract. Ibrutinib should be taken once daily at approximately the same time each day.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2013) "Product Information. Imbruvica (ibrutinib)." Pharmacyclics Inc
methoxsalen food
Applies to: Uvadex (methoxsalen)
GENERALLY AVOID: The ingestion of foods containing photosensitizing components (e.g., limes, figs, parsley, parsnips, rue (Ruta graveolens), mustard, carrots and celery) may increase the risk of photosensitivity and severe burning during methoxsalen therapy. Two cases of photosensitivity involving rue and a soup containing celery, parsley, and parsnip have been reported in PUVA patients.
MANAGEMENT: Patients who are undergoing PUVA treatment and taking methoxsalen should be advised to avoid eating large quantities of these foods.
References
- the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT), Royal Australian College of General Practicioners (RACGP), the Pharmaceutical Society of Australia (PSA) (2007) Australian Medicines Handbook. https://www.amh.net.au/
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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