Drug Interactions between Haldol Decanoate and Indocin
This report displays the potential drug interactions for the following 2 drugs:
- Haldol Decanoate (haloperidol)
- Indocin (indomethacin)
Interactions between your drugs
haloperidol indomethacin
Applies to: Haldol Decanoate (haloperidol) and Indocin (indomethacin)
One study has suggested that the combination of indomethacin and haloperidol frequently results in drowsiness and confusion. The mechanism is unknown. Close observation for adverse neurologic effects is indicated if these drugs must be used together. Use of a different neuroleptic agent may be necessary in some patients. Further data are needed to determine whether the adverse effect was simply due to the drowsiness normally induced by haloperidol, as well as whether other nonsteroidal anti-inflammatory drugs (NSAIDs) might interact with haloperidol.
References
- Bird HA, Le Gallez P, Wright V "Drowsiness due to halopericol/indomethacin in combination." Lancet 1 (1983): 830-1
Drug and food interactions
haloperidol food
Applies to: Haldol Decanoate (haloperidol)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):
indomethacin food
Applies to: Indocin (indomethacin)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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