Drug Interactions between glycopyrrolate / neostigmine and metrizamide

Before you undergo any imaging procedure where metrizamide may be injected directly into the spine, let your doctor know if you are currently being treated with neostigmine. Injection of metrizamide into the spine can sometimes cause seizures, and the risk may be increased if you are also using other medications that can cause seizures such as neostigmine. You may be more susceptible if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Your doctor may want to withhold neostigmine for a certain length of time before and after the procedure, or you may need to be monitored more closely during the procedure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Ask your doctor before using neostigmine together with glycopyrrolate. Using these medications together can cause increasing muscle weakness. In addition, such use may mask the less serious, gastrointestinal signs of glycopyrrolate overdose and lead to difficulty breathing, chest pain, and possibly death. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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