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Drug Interactions between fosphenytoin and Zyloprim

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

allopurinol fosphenytoin

Applies to: Zyloprim (allopurinol) and fosphenytoin

Limited clinical data suggest that allopurinol may increase phenytoin serum concentrations. The mechanism is unknown and causality is unclear. It is not known whether ethotoin and mephenytoin, which are similar hydantoin compounds, also participate in this interaction. The patient should be monitored for signs of phenytoin toxicity when allopurinol is added to an established phenytoin regimen. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.

References

  1. Yokochi K, Yokochi A, Chiba K, Ishizaki T (1982) "Phenytoin-allopurinol interaction: Michaelis-Menten kinetic parameters of phenytoin with and without allopurinol in a child with Lesch-Nyhan syndrome." Ther Drug Monit, 4, p. 353-7

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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