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Drug Interactions between foscarnet and gallium nitrate

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

foscarnet gallium nitrate

Applies to: foscarnet and gallium nitrate

MONITOR: Coadministration with other drugs that can reduce serum calcium may potentiate the risk of hypocalcemia associated with foscarnet. Foscarnet chelates with divalent metal ions and causes a dose-related reduction in ionized serum calcium. Hypocalcemia may occur in 15% to 30% of treated patients. Severe hypocalcemia (Trousseau's and Chvostek's signs) and fatalities have been reported rarely in postmarketing surveillance during use of foscarnet in combination with intravenous pentamidine. The interaction has not been reported with other drugs.

MANAGEMENT: Close monitoring is recommended during concomitant use of foscarnet with other drugs that are known to affect calcium concentrations. Serum creatinine and electrolyte levels should be assessed prior to initiating therapy and frequently during therapy. Patients should be advised to promptly notify their physician if they experience potential symptoms of hypocalcemia such as perioral tingling, numbness in extremities, and paresthesias.

References

  1. "Foscarnet: a review." Drugs 41 (1991): 106-29
  2. "Product Information. Foscavir (foscarnet)." Astra-Zeneca Pharmaceuticals PROD (2001):
  3. Youle M, Clarbour J, Gazzard B, Chanas A "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet 1 (1988): 1455-6

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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