Drug Interactions between fluvoxamine and Haldol
This report displays the potential drug interactions for the following 2 drugs:
- fluvoxamine
- Haldol (haloperidol)
Interactions between your drugs
haloperidol fluvoxaMINE
Applies to: Haldol (haloperidol) and fluvoxamine
MONITOR: The coadministration with fluvoxamine may increase the serum concentrations and pharmacologic effects of haloperidol. The exact mechanism is unknown but may involve fluvoxamine inhibition of CYP450 2D6, 3A4 and/or 1A2, the isoenzymes responsible for the metabolic clearance of haloperidol. In a randomized, crossover study involving four schizophrenic patients stabilized on haloperidol and benztropine, serum haloperidol concentrations increased significantly with increasing dosage and duration of fluvoxamine administration compared to placebo. Combination with fluvoxamine was also associated with significantly impaired performance on tests of delayed recall memory and attentional function. In addition to the pharmacokinetic changes, some investigators have suggested a pharmacodynamic interaction whereby serotonergic agents such as fluvoxamine may have modulating effects on dopaminergic systems, thus augmenting the effect of haloperidol and other neuroleptic agents.
MANAGEMENT: Caution is advised if haloperidol must be administered with fluvoxamine. Patients should be monitored for the development of extrapyramidal symptoms (e.g., tremor, shuffling gait, drooling, mask-like face, tongue stiffness, muscle spasms or rigidity, involuntary movements) and changes in mental status. A lower dosage of haloperidol may be required.
References
- Daniel DG, Randolph C, Jaskiw G, et al. "Coadministration of fluvoxamine increases serum concentrations of haloperidol." J Clin Psychopharmacol 14 (1994): 340-3
Drug and food interactions
haloperidol food
Applies to: Haldol (haloperidol)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):
fluvoxaMINE food
Applies to: fluvoxamine
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.