Drug Interactions between Fansidar and levamisole
This report displays the potential drug interactions for the following 2 drugs:
- Fansidar (pyrimethamine/sulfadoxine)
- levamisole
Interactions between your drugs
pyrimethamine sulfadoxine
Applies to: Fansidar (pyrimethamine / sulfadoxine) and Fansidar (pyrimethamine / sulfadoxine)
MONITOR: Coadministration of pyrimethamine in doses exceeding 25 mg per week with trimethoprim or sulfonamides may increase the risk of megaloblastic anemia and pancytopenia. The proposed mechanism is additive antifolate effects.
MANAGEMENT: Periodic clinical and laboratory monitoring for signs of folic acid deficiency and hematologic changes is advisable.
References
- "Multum Information Services, Inc. Expert Review Panel"
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Drug and food interactions
levamisole food
Applies to: levamisole
GENERALLY AVOID: Case histories have suggested that levamisole is associated with some side effects (including headache, fever, shivers, and dizziness) that suggest an disulfiram-like interaction with alcohol. These side effects could be alleviated by total abstinence from alcohol. No mechanism has been established for this interaction.
MANAGEMENT: Patients receiving levamisole should avoid alcohol.
References
- "Product Information. Ergamisol (levamisole)." Janssen Pharmaceuticals PROD (2001):
- Renoux G "The general immunopharmacology of levamisole." Drugs 19 (1980): 89-99
- Renoux G "Modulation of immunity by levamisole." Pharmacol Ther [B] 2 (1978): 397-422
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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