Drug Interactions between Eliquis and tafasitamab

MONITOR: Coadministration of tafasitamab with drugs that can affect hemostasis such as anticoagulants, platelet inhibitors, thrombin inhibitors, thrombolytic agents, dextrans, and nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of bleeding. Use of tafasitamab has been associated with serious or severe myelosuppression including thrombocytopenia, anemia, and neutropenia. In the L-MIND clinical efficacy study in which tafasitamab was given with lenalidomide for up to 12 cycles followed by tafasitamab monotherapy, the total incidence of thrombocytopenia during the combination therapy phase was 31%, with Grade 3 and Grade 4 thrombocytopenia occurring in 12% and 6% of subjects, respectively. After patients were switched to tafasitamab alone in the extended monotherapy phase, the incidences of haematological events including thrombocytopenia decreased by at least 20%.

MANAGEMENT: When possible, consideration should be given to withholding concomitant medications that may increase bleeding risk in patients treated with tafasitamab. Close clinical and laboratory monitoring for bleeding complications is recommended if concomitant use is unavoidable. Refer to the product labeling for guidance on frequency of laboratory monitoring and dose modifications or withholding recommendations for platelet counts below 50,000/mcL. Patients should be advised to promptly report any signs of unusual bleeding or bruising to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools.

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