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Drug Interactions between Doxil and procaine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

procaine DOXOrubicin liposomal

Applies to: procaine and Doxil (doxorubicin liposomal)

Limited in vitro data have shown that the two local anesthetics, procaine and lidocaine, can act synergistically with doxorubicin to inhibit cell growth. Data suggest that clinically achievable concentrations of these drugs could enhance doxorubicin cytotoxicity. The clinical relevance of these data is unknown.

References

  1. Chlebowski RT, Block JB, Cundiff D, Dietrich MF (1982) "Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line." Cancer Treat Rep, 66, p. 121-125

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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