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Drug Interactions between Doxil and mercaptopurine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

mercaptopurine DOXOrubicin liposomal

Applies to: mercaptopurine and Doxil (doxorubicin liposomal)

MONITOR: The concomitant administration of mercaptopurine with doxorubicin may increase the risk of hepatotoxicity. The mechanism is unknown. Hepatotoxic effects have been reported in patients receiving doxorubicin and high doses of intravenous mercaptopurine. The applicability to therapy with oral mercaptopurine is unknown.

MANAGEMENT: If concomitant therapy is needed, it is recommended to monitor patients for clinical and laboratory signs and symptoms of hepatotoxicity.

References

  1. (2001) "Product Information. Purinethol (mercaptopurine)." Glaxo Wellcome
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Cerner Multum, Inc. "Australian Product Information."
  4. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
View all 4 references

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Drug and food interactions

Moderate

mercaptopurine food

Applies to: mercaptopurine

ADJUST DOSING INTERVAL: Limited data suggest that food may decrease the oral bioavailability of 6-mercaptopurine (6-MP). In one study, the pharmacokinetics of 6-MP were studied on two separate occasions in seven patients. A single dose of 6-MP was administered after an overnight fast on one occasion and 15 minutes after a standard breakfast on the other. The authors reported that peak plasma levels of 6-MP were lower and took longer to reach following administration in the fed state. In addition, plasma levels were undetectable (less than 20 ng/mL) in two patients.

MANAGEMENT: Until more information is available regarding the effect of food on 6-MP absorption, it may be advisable to take 6-MP on an empty stomach 1 hour before or 2 hours after a meal.

References

  1. Schmidt LE, Dalhoff K (2002) "Food-drug interactions." Drugs, 62, p. 1481-502

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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