Drug Interactions between doxepin and Sotret
This report displays the potential drug interactions for the following 2 drugs:
- doxepin
- Sotret (isotretinoin)
Interactions between your drugs
No interactions were found between doxepin and Sotret. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
doxepin
A total of 694 drugs are known to interact with doxepin.
- Doxepin is in the following drug classes: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants.
-
Doxepin is used to treat the following conditions:
- Anxiety
- Depression
- Insomnia
- Irritable Bowel Syndrome (off-label)
- Major Depressive Disorder
- Neuropathic Pain (off-label)
- Reflex Sympathetic Dystrophy Syndrome (off-label)
- Urticaria
Sotret
A total of 130 drugs are known to interact with Sotret.
- Sotret is in the following drug classes: miscellaneous antineoplastics, miscellaneous uncategorized agents.
-
Sotret is used to treat the following conditions:
- Acne
- Acute Nonlymphocytic Leukemia (off-label)
- Granuloma Annulare (off-label)
- Rosacea (off-label)
Drug and food interactions
doxepin food
Applies to: doxepin
GENERALLY AVOID: Concomitant use of ethanol and a tricyclic antidepressant (TCA) may result altered TCA plasma levels and efficacy, and additive impairment of motor skills, especially driving skills. Acute ethanol ingestion may inhibit TCA metabolism, while chronic ingestion of large amounts of ethanol may induce hepatic TCA metabolism.
MANAGEMENT: Patients should be advised to avoid alcohol during TCA therapy. Alcoholics who have undergone detoxification should be monitored for decreased TCA efficacy. Dosage adjustments may be required.
References
- Dorian P, Sellers EM, Reed KL, et al. "Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction." Eur J Clin Pharmacol 25 (1983): 325-31
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Sandoz M, Vandel S, Vandel B, Bonin B, Allers G, Volmat R "Biotransformation of amitriptyline in alcoholic depressive patients." Eur J Clin Pharmacol 24 (1983): 615-21
- Ciraulo DA, Barnhill JG, Jaffe JH "Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers." Clin Pharmacol Ther 43 (1988): 509-18
- Seppala T, Linnoila M, Elonen E, Mattila MJ, Makl M "Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving." Clin Pharmacol Ther 17 (1975): 515-22
- Ciraulo DA, Barnhill JG, Jaffe JH, Ciraulo AM, Tarmey MF "Intravenous pharmacokinetics of 2-hydroxyimipramine in alcoholics and normal controls." J Stud Alcohol 51 (1990): 366-72
- Ciraulo DA, Alderson LM, Chapron DJ, Jaffe JH, Subbarao B, Kramer PA "Imipramine disposition in alcoholics." J Clin Psychopharmacol 2 (1982): 2-7
ISOtretinoin food
Applies to: Sotret (isotretinoin)
GENERALLY AVOID: The combined use of ethanol and isotretinoin may result in a disulfiram-like reaction. The mechanism has not been established.
MANAGEMENT: Alcohol consumption should be avoided during isotretinoin therapy.
References
- "Product Information. Accutane (isotretinoin)." Roche Laboratories PROD (2001):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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