Drug interactions between Diovan and Inspra
Results for the following 2 drugs: |
|
|---|---|
| Diovan (valsartan) | |
| Inspra (eplerenone) | |
Interactions between your selected drugs
valsartan ⇔ eplerenone
Applies to: Diovan (valsartan) and Inspra (eplerenone)
MONITOR: Coadministration of eplerenone with ACE inhibitors or angiotensin II receptor antagonists may increase the risk of hyperkalemia due to additive pharmacodynamic effects. According to the manufacturer, addition of eplerenone 50 to 100 mg to these agents increased mean serum potassium slightly, by about 0.09 to 0.13 mEq/L. However, the concomitant use of another mineralocorticoid receptor blocker with these agents has led to clinically relevant hyperkalemia. In a study of diabetics with microalbuminuria, the combination of eplerenone 200 mg and enalapril 10 mg resulted in increased frequency of hyperkalemia (i.e. serum potassium greater than 5.5 mEq/L) compared to enalapril alone (38% vs. 17%).
MANAGEMENT: Given the potential for serious, sometimes fatal cardiac arrhythmias associated with hyperkalemia, caution is advised if eplerenone is administered with ACE inhibitors or angiotensin II receptor antagonists. Periodic monitoring of serum potassium levels is recommended until the effect of eplerenone is established. In clinical trials, monitoring occurred every 2 weeks for the first 1 to 2 months, then monthly thereafter.
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