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Drug Interactions between digitoxin and Natpara

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

digitoxin parathyroid hormone

Applies to: digitoxin and Natpara (parathyroid hormone)

MONITOR CLOSELY: Parathyroid hormone may alter the effects of digitalis glycosides. The inotropic effects of digitalis glycosides are affected by serum calcium levels. Since parathyroid hormone causes a transient increase in serum calcium, it can potentiate the risk of digitalis toxicity if hypercalcemia develops. On the other hand, digitalis efficacy may be reduced if hypocalcemia occurs. Severe cases of both hypercalcemia and hypocalcemia have been reported during treatment with parathyroid hormone. The risk of hypercalcemia is greatest when starting or increasing the dose of parathyroid hormone, whereas the risk of hypocalcemia is greatest when parathyroid hormone is withheld, missed, or abruptly discontinued.

MANAGEMENT: Serum calcium and digitalis levels should be closely monitored during parathyroid hormone therapy, and the digitalis dosage adjusted as necessary. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
  3. (2015) "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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