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Drug Interactions between dengue vaccine and zoster vaccine live

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

zoster vaccine live dengue vaccine

Applies to: zoster vaccine live and dengue vaccine

ADJUST DOSING INTERVAL: The safety, immunogenicity, and efficacy of dengue vaccine when administered concurrently with other live viral or bacterial vaccines have not been adequately assessed. The U.S. Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices has reported that the live, attenuated, chimeric tetravalent dengue vaccine (Dengvaxia) did not have any safety issues or decreased immunogenicity when administered concomitantly with a yellow fever vaccine or a measles, mumps, and rubella (MMR) vaccine in infants and toddlers. However, a clinical study of a different live, attenuated, tetravalent dengue vaccine (Qdenga) in adults (n=300) reported a reduction in dengue antibody responses when administered concurrently with yellow fever 17D vaccine but no effect on the yellow fever seroprotection rate. The clinical significance of these findings is unknown. Clinical data evaluating the concomitant or sequential administration of dengue vaccine with other live vaccines are not available.

MANAGEMENT: The CDC's Advisory Committee on Immunization Practices generally recommends that doses of injectable, live attenuated vaccines not administered simultaneously be separated by an interval of at least 28 days. Current local immunization guidelines and prescribing information for individual vaccines should be consulted for specific recommendations.

References

  1. (2022) "Product Information. DENGVAXIA (dengue vaccine)." sanofi pasteur
  2. CDC Centers for Disease Control and Prevention (2022) Dengue Vaccine. Vaccine Schedule & Dosing. https://www.cdc.gov/dengue/vaccine/hcp/schedule-dosing.html
  3. Adams L, Paz-Bailey G, Wong JM, et al. (2022) Dengue Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021. MMWR Recomm Rep 2021 https://www.cdc.gov/mmwr/volumes/70/rr/rr7006a1.htm?s_cid=rr7006a1_w
  4. (2023) "Product Information. Qdenga (dengue vaccine)." Takeda UK Ltd
View all 4 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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