Drug interactions between Demerol and levodopa
| Results for the following 2 drugs: |
|---|
| Demerol (meperidine) |
| levodopa |
Interactions between your selected drugs
meperidine ↔ levodopa
Applies to:Demerol (meperidine) and levodopa
ADJUST DOSE: Central nervous system (CNS)- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking meperidine with other drugs that cause these effects, especially in elderly or debilitated patients. Profound sedation, delirium, hypotension, respiratory depression, or coma may occur.
MANAGEMENT: Extreme caution and dosage adjustments are recommended for patients receiving meperidine with other narcotic analgesics, anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, tricyclic antidepressants, and/or other CNS depressants. Meperidine dosage reductions of 25% to 50% are recommended for patients receiving phenothiazines and other tranquilizers. Patients should be closely monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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