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Drug Interactions between Cleviprex and magnesium sulfate

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

magnesium sulfate clevidipine

Applies to: magnesium sulfate and Cleviprex (clevidipine)

MONITOR: Coadministration of intravenous magnesium and nifedipine may result in hypotension and neuromuscular blockade. Several cases have been reported in pregnant patients with preeclampsia. The mechanism is unknown. Other calcium channel blockers may also interact. The risk may be increased in patients with renal impairment.

MANAGEMENT: The cardiovascular, respiratory, and neurologic status of patients should be closely monitored if these drugs must be given concurrently.

References

  1. Waisman GD, Mayorga LM, Camera MI, Vignolo CA, Martinotti A (1988) "Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia?" Am J Obstet Gynecol, 159, p. 308-9
  2. Snyder SW, Cardwell MS (1989) "Neuromuscular blockade with magnesium sulfate and nifedipine." Am J Obstet Gynecol, 161, p. 35-6
  3. (2002) "Product Information. Adalat (nifedipine)." Bayer
  4. Benami M, Giladi Y, Shalev E (1994) "The combination of magnesium sulphate and nifedipine - a cause of neuromuscular blockade." Br J Obstet Gynaecol, 101, p. 262-3
  5. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  6. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  7. Briggs GG, Yaffe SJ., Freeman RK (2011) "Drugs in Pregnancy and Lactation." Philadelphia, PA: Llippincott Williams & Wilkins
View all 7 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

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Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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