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Drug Interactions between citrulline and Rapaflo

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

citrulline silodosin

Applies to: citrulline and Rapaflo (silodosin)

MONITOR: Coadministration of L-arginine or L-citrulline may potentiate the hypotensive effects of nitrates and vasodilators. Both L-arginine and L-citrulline are amino acid precursors to nitric oxide, which causes vasodilation and increased blood flow.

MANAGEMENT: Due to potentially additive effects in the vasculature, caution is advised during concomitant use of L-arginine or L-citrulline with nitrates and vasodilators. Blood pressure and heart rate should be closely monitored.

References

  1. Stokes GS, Barin ES, Gilfillan KL, Kaesemeyer WH (2003) "Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave." Am J Hypertens, 16, p. 719-24

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Drug and food interactions

Moderate

silodosin food

Applies to: Rapaflo (silodosin)

ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of silodosin. The effect of a moderate-fat, moderate-calorie meal on silodosin pharmacokinetics was variable and decreased silodosin maximum plasma concentration (Cmax) by approximately 18% to 43% and systemic exposure (AUC) by 4% to 49% across three different studies. The maximum effect of food (i.e., coadministration with a high-fat, high-calorie meal) on the pharmacokinetics of silodosin was not evaluated. Safety and efficacy clinical trials for silodosin were always conducted in the presence of food intake.

MANAGEMENT: Patients should be instructed to take silodosin with a meal to reduce the risk of adverse events.

References

  1. (2008) "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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