Drug Interactions between citric acid/magnesium oxide/sodium picosulfate and zalcitabine
This report displays the potential drug interactions for the following 2 drugs:
- citric acid/magnesium oxide/sodium picosulfate
- zalcitabine
Interactions between your drugs
zalcitabine magnesium oxide
Applies to: zalcitabine and citric acid/magnesium oxide/sodium picosulfate
Magnesium and aluminum antacids have been shown to reduce the area under the curve of zalcitabine. The mechanism has not been described but may be due to chelation or alteration in gastrointestinal pH. Zalcitabine should be administered 2 hours prior to a magnesium and/or aluminum-containing antacid. The clinical significance of this interaction is unknown.
References
- "Product Information. HIVID (zalcitabine)." Roche Laboratories PROD (2001):
Drug and food interactions
sodium picosulfate food
Applies to: citric acid/magnesium oxide/sodium picosulfate
ADJUST DOSING INTERVAL: Bowel cleansing products can increase the gastrointestinal transit rate. Oral medications administered within one hour of the start of administration of the bowel cleansing solution may be flushed from the gastrointestinal tract and not properly absorbed.
MANAGEMENT: Patients should be advised that absorption of oral medications may be impaired during bowel cleansing treatment. Oral medications (e.g., anticonvulsants, oral contraceptives, antidiabetic agents, antibiotics) should not be administered during and within one hour of starting bowel cleansing treatment whenever possible. However, if concomitant use cannot be avoided, monitoring for reduced therapeutic effects may be advisable.
References
- "Product Information. Golytely (polyethylene glycol 3350 with electrolytes)." Braintree
- "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc (2022):
zalcitabine food
Applies to: zalcitabine
Zalcitabine bioavailability may be decreased by 14% if taken with meals. The mechanism and clinical significance are unknown.
References
- "Product Information. HIVID (zalcitabine)." Roche Laboratories PROD (2001):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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