Drug interactions between ciprofloxacin and Synthroid
| Results for the following 2 drugs: |
|---|
| ciprofloxacin |
| Synthroid (levothyroxine) |
Interactions between your selected drugs
ciprofloxacin ↔ levothyroxine
Applies to:ciprofloxacin and Synthroid (levothyroxine)
ADJUST DOSING INTERVAL: Limited data suggest that simultaneous administration of oral ciprofloxacin may interfere with the gastrointestinal absorption of levothyroxine. The mechanism has not been described. In one case report, two elderly patients stabilized on levothyroxine therapy developed hypothyroidism three and four weeks after starting treatment with oral ciprofloxacin. Other concomitant medications were unchanged. In one of the patients, increasing the dosage of levothyroxine had no effect, and thyroid function tests normalized only after discontinuation of ciprofloxacin. In the other patient, thyroid function tests normalized soon after switching from concomitant administration of levothyroxine and ciprofloxacin to administration with a six hour gap.
MANAGEMENT: Although data are limited, it may be prudent to advise patients to separate administration of levothyroxine and ciprofloxacin by several hours to minimize the potential for interaction.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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