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Drug Interactions between Choledyl and Northyx

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

methIMAzole oxtriphylline

Applies to: Northyx (methimazole) and Choledyl (oxtriphylline)

MONITOR: Clearance of theophylline and related agents depends upon thyroid function. In the hyperthyroid state, clearance may be enhanced. In the hypothyroid state, clearance may be reduced. Theophylline clearance may decrease and the risk of toxicity may increase when hyperthyroid patients become euthyroid.

MANAGEMENT: The patient and theophylline levels should be closely monitored while achieving a euthyroid state and when an antithyroid agent is added, discontinued, or the dosage is changed. Theophylline dosage adjustments may be required. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms, or any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or irregular heartbeats.

References

  1. Aderka D, Shavit G, Garfinkel D, et al. "Life-threatening theophylline intoxication in a hypothyroid patient." Respiration 44 (1983): 77-80
  2. Bauman JH, Teichman S, Wible DA "Increased theophylline clearance in a patient with hyperthyroidism." Ann Allergy 52 (1984): 94-6
  3. "Product Information. Tapazole (methimazole)." King Pharmaceuticals Inc PROD (2001):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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