Drug interactions between Celebrex and Lithobid
Results for the following 2 drugs: |
|
|---|---|
| Celebrex (celecoxib) | |
| Lithobid (lithium) | |
Interactions between your selected drugs
lithium ⇔ celecoxib
Applies to: Lithobid (lithium) and Celebrex (celecoxib)
MONITOR: Several case reports and small studies suggest that some nonsteroidal anti-inflammatory drugs (NSAIDs) may increase serum lithium levels and increase the risk of toxicity. The exact mechanism is unknown but may involve inhibition of renal prostaglandin synthesis by NSAIDs. Lithium toxicity has been reported during concomitant use of indomethacin, ketorolac, mefenamic acid, and piroxicam. Lithium plasma concentrations have been shown to increase in healthy subjects or patients taking various NSAIDs including celecoxib, diflunisal, flurbiprofen, meloxicam, naproxen, and valdecoxib. Limited data suggest that sulindac may participate in the interaction to a lesser extent than do other NSAIDs. Aspirin and other salicylates do not appear to interact with lithium.
MANAGEMENT: Patients who must take lithium in combination with NSAIDs should be monitored for evidence of lithium toxicity, although clinically significant interactions are thought to be rare. More frequent monitoring of lithium levels is recommended. Patients should be advised to notify their physician if they experience potential signs and symptoms of lithium toxicity such as drowsiness, dizziness, confusion, weakness, ataxia, tremor, tinnitus, blurred vision, vomiting, diarrhea, thirst, and increased urination.
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