Drug Interactions between cefiderocol and Jesduvroq
This report displays the potential drug interactions for the following 2 drugs:
- cefiderocol
- Jesduvroq (daprodustat)
Interactions between your drugs
cefiderocol daprodustat
Applies to: cefiderocol and Jesduvroq (daprodustat)
MONITOR: Coadministration with inducers of CYP450 2C8 may decrease daprodustat plasma concentrations and may result in loss of efficacy. The proposed mechanism is induction of CYP450 2C8-mediated metabolism of daprodustat, which is primarily metabolized by the isoenzyme. However, data evaluating the interaction are not available.
MANAGEMENT: Increased monitoring of hemoglobin levels is advised following initiation or discontinuation of treatment with CYP450 2C8 inducers and the dupradustat dosage may be adjusted as necessary.
References
- (2023) "Product Information. Jesduvroq (daprodustat)." GlaxoSmithKline
Drug and food interactions
daprodustat food
Applies to: Jesduvroq (daprodustat)
MONITOR: Smoking and alcohol consumption during therapy with daprodustat may increase the risk of gastric or esophageal erosions. Serious erosions, including gastrointestinal bleeding and the need for red blood cell transfusions, have been reported during daprodustat clinical trials. Patients with a history of gastrointestinal erosion, peptic ulcer disease, and current tobacco smokers and alcohol drinkers may be at higher risk of gastrointestinal injury.
MANAGEMENT: Caution is advised if daprodustat is prescribed to current tobacco smokers or alcohol drinkers. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.
References
- (2023) "Product Information. Jesduvroq (daprodustat)." GlaxoSmithKline
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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