Drug interactions between Cardizem and digoxin
| Results for the following 2 drugs: |
|---|
| Cardizem (diltiazem) |
| digoxin |
Interactions between your selected drugs
diltiazem ↔ digoxin
Applies to:Cardizem (diltiazem) and digoxin
MONITOR: Diltiazem may cause increases in digoxin plasma levels although reports are conflicting. The mechanism for this possible interaction is unknown but is thought to be related to diltiazem-induced decreases in digoxin clearance. In addition, digoxin and diltiazem have additive effects in slowing AV conduction.
MANAGEMENT: Monitor for signs and symptoms of digoxin toxicity, checking digoxin levels when clinically necessary. Patients should be advised to notify their physicians if they experience signs of digoxin toxicity such as nausea, anorexia, visual changes, slow pulse, or irregular heartbeats. Calcium channel blockers such as felodipine, or amlodipine, isradipine, and nicardipine appear to affect digoxin levels to a lesser extent or not at all and may be considered as alternatives.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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