Drug interactions between Biaxin and Prozac
Results for the following 2 drugs: |
|
|---|---|
| Biaxin (clarithromycin) | |
| Prozac (fluoxetine) | |
Interactions between your selected drugs
clarithromycin ⇔ fluoxetine
Applies to: Biaxin (clarithromycin) and Prozac (fluoxetine)
GENERALLY AVOID: The use of some macrolide antibiotics has been associated with increased blood levels of some selective serotonin reuptake inhibitors (SSRIs), resulting in excessive serotonergic effects or serotonin syndrome. The mechanism is inhibition of the CYP450 3A4 isoenzyme, which metabolizes SSRIs.
MANAGEMENT: In cases where both drugs are necessary, one could consider using a macrolide antibiotic that does not inhibit CYP450 3A4, such as azithromycin or dirithromycin.
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