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Drug Interactions between bevacizumab and Doxil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

DOXOrubicin liposomal bevacizumab

Applies to: Doxil (doxorubicin liposomal) and bevacizumab

GENERALLY AVOID: Coadministration of bevacizumab and anthracyclines may increase the risk of cardiac dysfunction. Bevacizumab and anthracyclines are individually cardiotoxic and may have additive effects during coadministration. Among patients who received prior anthracycline treatment, the incidence of congestive heart failure (CHF) was 4% for patients receiving bevacizumab with chemotherapy compared to 0.6% for patients receiving chemotherapy alone. In previously untreated patients with hematologic malignancy, the proportion of patients with a decline in left ventricular ejection fraction (LVEF) from baseline of 20% or more or a decline from baseline of 10% to less than 50%, was 10% in patients receiving bevacizumab with anthracycline-based chemotherapy compared to 5% in patients receiving the same chemotherapy regimen alone.

MANAGEMENT: Bevacizumab is not indicated for use with anthracycline-based chemotherapy. Some authorities recommend avoiding bevacizumab during and for at least 12 months after stopping anthracycline-containing treatment.

References

  1. "Product Information. Avastin (bevacizumab)." Genentech (2004):
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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