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Drug Interactions between Bel-Phen-Ergot and lasmiditan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

ergotamine lasmiditan

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital) and lasmiditan

Using ergotamine together with lasmiditan can increase the risk of a rare but serious condition called serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should seek immediate medical attention if you experience these symptoms while taking the medications. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ergotamine PHENobarbital

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital) and Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital)

PHENobarbital may reduce the blood levels and effects of ergotamine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

PHENobarbital lasmiditan

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital) and lasmiditan

Lasmiditan may cause sedation, dizziness, and impaired driving ability. The risk and/or severity may be increased when combined with alcohol or other medications that can also cause sedation. Let your doctor know prior to receiving lasmiditan if you are currently using alcohol or receiving treatment with PHENobarbital, as you may be more likely to experience sedation-related side effects. Tell your healthcare provider right away if you feel like you cannot stay awake during the time you are normally awake or if you feel like you are going to pass out. Your healthcare provider may lower your dose or stop the medication until your symptoms go away. Do not drive, operate machinery, or engage in potentially hazardous activities requiring mental alertness and motor coordination until the sedative effects have gone away and you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

belladonna lasmiditan

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital) and lasmiditan

Lasmiditan may cause sedation, dizziness, and impaired driving ability. The risk and/or severity may be increased when combined with alcohol or other medications that can also cause sedation. Let your doctor know prior to receiving lasmiditan if you are currently using alcohol or receiving treatment with belladonna, as you may be more likely to experience sedation-related side effects. Tell your healthcare provider right away if you feel like you cannot stay awake during the time you are normally awake or if you feel like you are going to pass out. Your healthcare provider may lower your dose or stop the medication until your symptoms go away. Do not drive, operate machinery, or engage in potentially hazardous activities requiring mental alertness and motor coordination until the sedative effects have gone away and you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

PHENobarbital food

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital)

Ask your doctor before using PHENobarbital together with ethanol, this can add to dizziness, drowsiness and other side effects of PHENobarbital. Be careful if you drive or do activities that require you to be awake and alert. Talk with your doctor before using any medications together, or drinking alcohol with PHENobarbital. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ergotamine food

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital)

Grapefruit juice may increase the blood levels of certain medications such as ergotamine. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Moderate

belladonna food

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital)

Ask your doctor before using belladonna together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking belladonna. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ergotamine food

Applies to: Bel-Phen-Ergot (belladonna / ergotamine / phenobarbital)

Nicotine may increase the effects of ergotamine in narrowing the blood vessels and decreasing blood flow. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects. Contact your doctor immediately if you experience coldness, paleness, discoloration, numbness, tingling, or pain in your hands or feet; muscle pain or weakness; severe or worsening headache; blurred vision; severe abdominal pain; chest pain; or shortness of breath while using these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Sympatholytics

Therapeutic duplication

The recommended maximum number of medicines in the 'sympatholytics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'sympatholytics' category:

  • Bel-Phen-Ergot (belladonna/ergotamine/phenobarbital)
  • lasmiditan

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

Duplication

Ergot-like drugs

Therapeutic duplication

The recommended maximum number of medicines in the 'ergot-like drugs' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'ergot-like drugs' category:

  • Bel-Phen-Ergot (belladonna/ergotamine/phenobarbital)
  • lasmiditan

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.