Drug Interactions between Bayer Women's Aspirin With Calcium and lecanemab
This report displays the potential drug interactions for the following 2 drugs:
- Bayer Women's Aspirin With Calcium (aspirin)
- lecanemab
Interactions between your drugs
aspirin lecanemab
Applies to: Bayer Women's Aspirin With Calcium (aspirin) and lecanemab
MONITOR CLOSELY: Coadministration with drugs that can affect hemostasis such as glycoprotein IIb/IIIa inhibitors, thienopyridine antiplatelet agents, unfractionated and low molecular weight heparins, heparin derivatives, hirudin derivatives and analogs, thrombolytics, vitamin K antagonists, factor Xa inhibitors and other anticoagulants may potentiate the risk of bleeding complications associated with the use of the amyloid beta-directed antibody, lecanemab. Lecanemab therapy has been associated with amyloid related imaging abnormalities (ARIA) with hemosiderin deposition (ARIA-H), including microhemorrhage, superficial siderosis, and intracerebral hemorrhage, including fatal events. According to limited clinical trial data, concomitant use of lecanemab with aspirin, other antiplatelets (e.g., clopidogrel), or anticoagulants (e.g., dabigatran or warfarin) did not lead to an increased risk of ARIA-H compared to placebo; however, the majority of patients who received lecanemab were exposed to aspirin only so no definitive conclusions are possible. In addition, patients with known risk factors for intracerebral hemorrhage were excluded from clinical trials.
MANAGEMENT: Due to the risk of intracerebral hemorrhage, caution and close monitoring are recommended with the use of anticoagulants, antiplatelets, antithrombotics, or thrombolytic agents in patients already being treated with lecanemab, particularly those with risk factors for intracerebral hemorrhage.
References
- (2023) "Product Information. Leqembi (lecanemab)." Eisai Inc, 1
Drug and food interactions
aspirin food
Applies to: Bayer Women's Aspirin With Calcium (aspirin)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
aspirin food
Applies to: Bayer Women's Aspirin With Calcium (aspirin)
One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
References
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A (1986) "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet, 11, p. 71-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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