Drug Interactions between aspirin and Vantin
This report displays the potential drug interactions for the following 2 drugs:
- aspirin
- Vantin (cefpodoxime)
Interactions between your drugs
No interactions were found between aspirin and Vantin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
aspirin
A total of 343 drugs are known to interact with aspirin.
- Aspirin is in the following drug classes: platelet aggregation inhibitors, salicylates.
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Aspirin is used to treat the following conditions:
- Angina
- Angina Pectoris Prophylaxis
- Ankylosing Spondylitis
- Antiphospholipid Syndrome
- Aseptic Necrosis
- Back Pain
- Fever
- Heart Attack
- Ischemic Stroke
- Ischemic Stroke, Prophylaxis
- Juvenile Rheumatoid Arthritis
- Kawasaki Disease
- Lupus
- Myocardial Infarction, Prophylaxis
- Niacin Flush
- Osteoarthritis
- Pain
- Pain/Fever
- Prevention of Thromboembolism in Atrial Fibrillation
- Prosthetic Heart Valves - Thrombosis Prophylaxis
- Prosthetic Heart Valves, Mechanical Valves - Thrombosis Prophylaxis
- Revascularization Procedures, Prophylaxis
- Rheumatic Fever
- Rheumatoid Arthritis
- Sciatica
- Spondyloarthritis
- Thromboembolic Stroke Prophylaxis
- Transient Ischemic Attack
Vantin
A total of 67 drugs are known to interact with Vantin.
- Vantin is in the drug class third generation cephalosporins.
- Vantin is used to treat the following conditions:
Drug and food interactions
cefpodoxime food
Applies to: Vantin (cefpodoxime)
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of cefpodoxime proxetil tablets. Following a 200 mg dose taken with food, the extent of absorption (mean AUC) was 21% to 33% higher and the mean peak plasma concentration (Cmax) 19% higher than under fasting conditions. Time to peak concentration (Tmax) was not significantly different between fed and fasted states. On the contrary, when a 200 mg dose of the suspension was taken with food, the mean AUC and Cmax were not significantly different than those under fasting conditions, although the rate of absorption was slower with food (48% increase in Tmax ).
MANAGEMENT: To ensure maximal oral absorption, cefpodoxime proxetil tablets should be administered with or immediately after a meal.
References
- Hughes GS, Heald DL, Barker KB, et al. "The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil." Clin Pharmacol Ther 46 (1989): 674-85
- "Product Information. Vantin (cefpodoxime)." Pharmacia and Upjohn PROD
- Borin MT, Driver MR, Forbes KK "Effect of timing of food on absorption of cefpodoxime proxetil." J Clin Pharmacol 35 (1995): 505-9
aspirin food
Applies to: aspirin
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
aspirin food
Applies to: aspirin
One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
References
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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