Drug Interactions between Arthritis Foundation Pain Reliever and griseofulvin
This report displays the potential drug interactions for the following 2 drugs:
- Arthritis Foundation Pain Reliever (aspirin)
- griseofulvin
Interactions between your drugs
griseofulvin aspirin
Applies to: griseofulvin and Arthritis Foundation Pain Reliever (aspirin)
One pediatric case report has suggested that griseofulvin may decrease serum salicylate (aspirin) concentrations. The mechanism suggested by the authors is interference with salicylate absorption. The authors have recommended that griseofulvin be avoided if possible when therapy with anti-inflammatory doses of salicylate are required. If these drugs must be given together, staggered doses and careful monitoring of salicylate levels are recommended.
References
- Phillips KR, Wideman SD, Cochran EB, Becker JA (1993) "Griseofulvin significantly decreases serum salicylate concentrations." Pediatr Infect Dis J, 12, p. 350-2
Drug and food interactions
griseofulvin food
Applies to: griseofulvin
MONITOR: Isolated case reports have suggested that the ingestion of alcohol during griseofulvin therapy may rarely cause disulfiram-like reactions, flushing, tachycardia, or increased effects of alcohol. The mechanism is unknown.
MANAGEMENT: Patients should be advised of the possibility of increased adverse effects or a disulfiram-like reaction.
References
- "Product Information. Grifulvin V (griseofulvin)." Ortho McNeil Pharmaceutical
- (2002) "Product Information. Fulvicin P/G (griseofulvin)." Schering Corporation
- Cerner Multum, Inc. "Australian Product Information."
aspirin food
Applies to: Arthritis Foundation Pain Reliever (aspirin)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
aspirin food
Applies to: Arthritis Foundation Pain Reliever (aspirin)
One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
References
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A (1986) "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet, 11, p. 71-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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