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Drug Interactions between arginine and Voxsuprine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

arginine isoxsuprine

Applies to: arginine and Voxsuprine (isoxsuprine)

MONITOR: Coadministration of L-arginine or L-citrulline may potentiate the hypotensive effects of nitrates and vasodilators. Both L-arginine and L-citrulline are amino acid precursors to nitric oxide, which causes vasodilation and increased blood flow.

MANAGEMENT: Due to potentially additive effects in the vasculature, caution is advised during concomitant use of L-arginine or L-citrulline with nitrates and vasodilators. Blood pressure and heart rate should be closely monitored.

References

  1. Stokes GS, Barin ES, Gilfillan KL, Kaesemeyer WH (2003) "Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave." Am J Hypertens, 16, p. 719-24

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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