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Drug Interactions between Antilirium and Timoptic

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

PHYSostigmine timolol ophthalmic

Applies to: Antilirium (physostigmine) and Timoptic (timolol ophthalmic)

MONITOR: Severe bradycardia and hypotension may develop during concomitant administration of some beta-blockers and anticholinesterase agents. The mechanism is unknown but may involve additive effects. Data have been conflicting. Some studies have reported no significant changes.

MANAGEMENT: The patient's hemodynamic status should be monitored during coadministration. Patients should be advised to notify their physician if they experience syncope, orthostasis, or a slow pulse.

References

  1. Eldor J, Hoffman B, Davidson JT "Prolonged bradycardia and hypotension after neostigmine administration in a patient receiving atenolol." Anaesthesia 42 (1987): 1294-7

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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