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Drug Interactions between amphotericin b lipid complex and Neo-Fradin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

neomycin amphotericin B lipid complex

Applies to: Neo-Fradin (neomycin) and amphotericin b lipid complex

MONITOR: The potential nephrotoxicity associated with amphotericin B and aminoglycosides may be additive.

MANAGEMENT: Just before the start and just before the end of each amphotericin infusion, hydration of the patient with 500 mL of normal saline may be helpful. The patient's renal function should be monitored frequently during therapy.

References

  1. Churchill DN, Seely J "Nephrotoxicity associated with combined gentamicin - amphotericin B therapy." Nephron 19 (1977): 176-81
  2. "Product Information. Abelcet (amphotericin B lipid complex)." Liposome Company Inc, The
  3. "Product Information. Arikayce (amikacin liposome)." Insmed Incorporated (2018):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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