Drug Interactions between amitriptyline and Uceris
This report displays the potential drug interactions for the following 2 drugs:
- amitriptyline
- Uceris (budesonide)
Interactions between your drugs
No interactions were found between amitriptyline and Uceris. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
amitriptyline
A total of 705 drugs are known to interact with amitriptyline.
- Amitriptyline is in the drug class tricyclic antidepressants.
-
Amitriptyline is used to treat the following conditions:
- Anxiety and Stress (off-label)
- Burning Mouth Syndrome (off-label)
- Chronic Myofascial Pain (off-label)
- Chronic Pain
- Cough (off-label)
- Cyclic Vomiting Syndrome (off-label)
- Depression
- Depressive Psychosis (off-label)
- Dysautonomia (off-label)
- Fibromyalgia (off-label)
- Headache
- Hyperhidrosis (off-label)
- Insomnia (off-label)
- Interstitial Cystitis (off-label)
- Irritable Bowel Syndrome (off-label)
- Migraine
- Migraine Prevention (off-label)
- Neuropathic Pain (off-label)
- Neurotic Depression (off-label)
- Pain (off-label)
- Persistent Depressive Disorder (off-label)
- Post Traumatic Stress Disorder (off-label)
- Pudendal Neuralgia (off-label)
- Reflex Sympathetic Dystrophy Syndrome (off-label)
- Somatoform Pain Disorder (off-label)
- Urinary Incontinence (off-label)
- Vulvodynia (off-label)
Uceris
A total of 511 drugs are known to interact with Uceris.
- Uceris is in the drug class glucocorticoids.
- Uceris is used to treat the following conditions:
Drug and food interactions
budesonide food
Applies to: Uceris (budesonide)
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations and systemic effects of orally administered budesonide. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. According to the manufacturer, the systemic exposure of oral budesonide approximately doubles after extensive intake of grapefruit juice.
MANAGEMENT: Patients receiving budesonide should avoid the regular consumption of grapefruits and grapefruit juice to prevent undue increases in plasma budesonide levels and systemic effects.
References
- "Product Information. Entocort (budesonide)." AstraZeneca Pharma Inc (2001):
amitriptyline food
Applies to: amitriptyline
GENERALLY AVOID: Concomitant use of ethanol and a tricyclic antidepressant (TCA) may result altered TCA plasma levels and efficacy, and additive impairment of motor skills, especially driving skills. Acute ethanol ingestion may inhibit TCA metabolism, while chronic ingestion of large amounts of ethanol may induce hepatic TCA metabolism.
MANAGEMENT: Patients should be advised to avoid alcohol during TCA therapy. Alcoholics who have undergone detoxification should be monitored for decreased TCA efficacy. Dosage adjustments may be required.
References
- Dorian P, Sellers EM, Reed KL, et al. "Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction." Eur J Clin Pharmacol 25 (1983): 325-31
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Sandoz M, Vandel S, Vandel B, Bonin B, Allers G, Volmat R "Biotransformation of amitriptyline in alcoholic depressive patients." Eur J Clin Pharmacol 24 (1983): 615-21
- Ciraulo DA, Barnhill JG, Jaffe JH "Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers." Clin Pharmacol Ther 43 (1988): 509-18
- Seppala T, Linnoila M, Elonen E, Mattila MJ, Makl M "Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving." Clin Pharmacol Ther 17 (1975): 515-22
- Ciraulo DA, Barnhill JG, Jaffe JH, Ciraulo AM, Tarmey MF "Intravenous pharmacokinetics of 2-hydroxyimipramine in alcoholics and normal controls." J Stud Alcohol 51 (1990): 366-72
- Ciraulo DA, Alderson LM, Chapron DJ, Jaffe JH, Subbarao B, Kramer PA "Imipramine disposition in alcoholics." J Clin Psychopharmacol 2 (1982): 2-7
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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