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Drug Interactions between allopurinol and Bendeka

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

allopurinol bendamustine

Applies to: allopurinol and Bendeka (bendamustine)

MONITOR: Coadministration of bendamustine with allopurinol may increase the risk of severe skin reactions. Rare cases of Stevens-Johnson syndrome and toxic epidermal necrolysis, some fatal, have been reported when bendamustine was administered concomitantly with allopurinol and other medications known to be associated with these toxicities. The potential mechanism of interaction has not been established.

MANAGEMENT: Although allopurinol may be given to prevent tumor lysis syndrome during treatment with bendamustine, caution is advised when these medications are used together. Because skin reactions may be progressive and increase in severity with further treatment, patients who develop skin reactions should be closely monitored. The manufacturer recommends that bendamustine be withheld or discontinued if skin reactions are severe or progressive.

References

  1. (2008) "Product Information. Treanda (bendamustine)." Cephalon Inc
  2. (2016) "Product Information. Bendeka (bendamustine)." Teva Pharmaceuticals USA

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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