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Drug Interactions between aldesleukin and Omnipaque 140

This report displays the potential drug interactions for the following 2 drugs:

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Major

aldesleukin iohexol

Applies to: aldesleukin and Omnipaque 140 (iohexol)

GENERALLY AVOID: Intrathecal administration of iodinated contrast media may induce seizures. There may be a theoretical risk of increased seizure potential when iodinated contrast agents are used with other substances that can reduce the seizure threshold such as aldesleukin.

MONITOR CLOSELY: An increased incidence (12.6%) of acute, atypical reactions to iodinated contrast media has been observed in patients who have been previously treated with interleukin-2. The cause and mechanism have not been established. Symptoms generally have an onset of 1 to 4 hours and may include nausea, vomiting, diarrhea, fever, chills, rash, pruritus, hypotension, edema, and oliguria. Reactions have typically been reported when patients received iodinated contrast media within 4 weeks after the last dose of interleukin-2, but have also occurred several months after interleukin treatment.

MANAGEMENT: Aldesleukin should preferably be withheld for at least 48 hours prior to and 24 hours following intrathecal administration of iodinated contrast media. Patients should be monitored for adverse reactions during and after the myelography, and symptomatic treatment initiated as clinically appropriate.

References

  1. "Product Information. Proleukin (aldesleukin)." Chiron Therapeutics PROD (2001):
  2. "Product Information. Osmovist 240 (iotrolan)." Berlex Canada Inc (2001):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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