Drug interactions between Adriamycin and paclitaxel
Results for the following 2 drugs: |
|
|---|---|
| Adriamycin (doxorubicin) | |
| paclitaxel | |
Interactions between your selected drugs
doxorubicin ⇔ paclitaxel
Applies to: Adriamycin (doxorubicin) and paclitaxel
MONITOR: Two cases of typhlitis (neutropenic enterocolitis) have occurred in patients with metastatic breast cancer following combined treatment with paclitaxel and doxorubicin given simultaneously as 72-hour continuous intravenous infusions, while typhlitis has not been described after treatment with either drug alone. The mechanism of interaction is unknown. These drugs have been used together for the treatment of some cancers. More data are needed.
MANAGEMENT: Close monitoring for clinical and laboratory evidence of adverse effects is recommended during coadministration of paclitaxel and doxorubicin. In vitro data have shown that sequential administration in which paclitaxel is followed by doxorubicin may be the most effective and suitable.
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