Teduglutide Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Short Bowel Syndrome

In Patients Dependent on Parenteral Support:
0.05 mg/kg body weight subcutaneously once daily

Comments: Rotation of injection sites recommended (thighs, arms, and quadrants of the abdomen)

Renal Dose Adjustments

Mild renal dysfunction: No adjustment recommended.
Moderate to severe renal dysfunction (CrCl less than 50 mL/min) and end-stage renal disease: Reduce dose by 50%

Liver Dose Adjustments

Mild to moderate liver dysfunction (Child-Pugh B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Data not available

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Not for intravenous or intramuscular use
-Drug should be completely dissolved prior to withdrawing from vial.
-Use within 3 hours of reconstitution.
-Do not shake or freeze reconstituted solution.
-Discard any unused portion.

Storage requirements:
-Prior to dispensing: Refrigerate vials and one-vial kits. Do not freeze.

Reconstitution/preparation techniques: The manufacturer's product information should be consulted.

Patient advice:
-Subcutaneous administration can cause injection site reactions
-Abdominal pain and swelling of stoma may occur when starting treatment
-Report any symptoms of intestinal obstruction, pancreatic disease, gallbladder and bile duct disease, and fluid overload or cardiac decompensation
-Report any concomitant oral medications, especially benzodiazepines and psychotropic agents

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