Sulfinpyrazone Dosage
Applies to the following strengths: 100 mg; 200 mg
Usual Adult Dose for Gouty Arthritis
Initial: 200 to 400 mg orally given in 2 equally divided doses, with meals or milk, gradually increasing when necessary to full maintenance dosage in 1 week.
Maintenance: 400 mg daily in 2 equally divided doses; may increase to 800 mg daily or reduce to as low as 200 mg daily after the blood urate level has been controlled. Continue treatment without interruption even in the presence of acute exacerbations, which can be concomitantly treated with colchicine. Patients previously controlled with other uricosuric therapy may be transferred to sulfinpyrazone at full maintenance dosage.
Other Comments
Avoid administering sulfinpyrazone to patients with active peptic ulcer or symptoms of GI inflammation or ulceration or patients with blood dyscrasias.
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