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Selegiline Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Parkinson's Disease

Adjunct to levodopa/carbidopa:

Oral tablet: 5 mg twice a day at breakfast and lunch.

Oral disintegrating tablet: 1.25 mg once a day, before breakfast, for at least 6 weeks. After 6 weeks, the dose may be increased to 2.5 mg once a day if needed.

Usual Adult Dose for Depression

Major Depressive Disorder:

Initial: Apply one transdermal patch (6 mg/24 hours) to intact skin once every 24 hours.
Maintenance: 6 mg/24 hours up to a maximum of 12 mg/24 hours.

Renal Dose Adjustments

Transdermal System: No adjustments recommended for patients with mild, moderate, or severe renal impairment.

Oral: No data available for use in renally impaired patients.

Liver Dose Adjustments

Transdermal System: No adjustments are recommended in patients with mild or moderate liver impairment (Child-Pugh classification of A or B).

Oral: No data available for use in hepatically impaired patients, but caution is advised.

Dose Adjustments

Transdermal system: Dosage may be adjusted upwards in 3 mg/24 hours increments at intervals of no less than two weeks.

Oral tablet: after two to three days of treatment, an attempt may be made to reduce the dose of levodopa-carbidopa.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Patients should avoid ingesting food or liquids for 5 minutes before and after taking selegiline orally disintegrating tablets.

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