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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Parkinson's Disease
Adjunct to levodopa/carbidopa:
Oral tablet: 5 mg twice a day at breakfast and lunch.
Oral disintegrating tablet: 1.25 mg once a day, before breakfast, for at least 6 weeks. After 6 weeks, the dose may be increased to 2.5 mg once a day if needed.
Usual Adult Dose for Depression
Major Depressive Disorder:
Initial: Apply one transdermal patch (6 mg/24 hours) to intact skin once every 24 hours.
Maintenance: 6 mg/24 hours up to a maximum of 12 mg/24 hours.
Renal Dose Adjustments
Transdermal System: No adjustments recommended for patients with mild, moderate, or severe renal impairment.
Oral: No data available for use in renally impaired patients.
Liver Dose Adjustments
Transdermal System: No adjustments are recommended in patients with mild or moderate liver impairment (Child-Pugh classification of A or B).
Oral: No data available for use in hepatically impaired patients, but caution is advised.
Transdermal system: Dosage may be adjusted upwards in 3 mg/24 hours increments at intervals of no less than two weeks.
Oral tablet: after two to three days of treatment, an attempt may be made to reduce the dose of levodopa-carbidopa.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Data not available
Patients should avoid ingesting food or liquids for 5 minutes before and after taking selegiline orally disintegrating tablets.
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