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Selegiline Dosage

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Parkinson's Disease

Adjunct to levodopa/carbidopa:

Oral tablet: 5 mg twice a day at breakfast and lunch.

Oral disintegrating tablet: 1.25 mg once a day, before breakfast, for at least 6 weeks. After 6 weeks, the dose may be increased to 2.5 mg once a day if needed.

Usual Adult Dose for Depression

Major Depressive Disorder:

Initial: Apply one transdermal patch (6 mg/24 hours) to intact skin once every 24 hours.
Maintenance: 6 mg/24 hours up to a maximum of 12 mg/24 hours.

Renal Dose Adjustments

Transdermal System: No adjustments recommended for patients with mild, moderate, or severe renal impairment.

Oral: No data available for use in renally impaired patients.

Liver Dose Adjustments

Transdermal System: No adjustments are recommended in patients with mild or moderate liver impairment (Child-Pugh classification of A or B).

Oral: No data available for use in hepatically impaired patients, but caution is advised.

Dose Adjustments

Transdermal system: Dosage may be adjusted upwards in 3 mg/24 hours increments at intervals of no less than two weeks.

Oral tablet: after two to three days of treatment, an attempt may be made to reduce the dose of levodopa-carbidopa.


Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


Data not available

Other Comments

Patients should avoid ingesting food or liquids for 5 minutes before and after taking selegiline orally disintegrating tablets.